Banana is a major export commodity in the Philippines with exports valued at US$1000 million in 2013. However, the incursion of Fusarium wilt Tropical Race 4 (TR4) (Fusarium oxysporum f. sp. cubense) has seriously jeopardised the export banana industry. To reduce the impacts of TR4 on banana production, field and greenhouse pot experiments were established to investigate the standard production methods of Grand Naine with the use of resistant clones GCTCV 218 in modified production systems. In the greenhouse experiment, Grand Naine inoculated with TR4 was grown with four groundcovers species alone or in combinations and compared with GCTCV 218, GCTCV 219, and bare soil. The field experiment was established on a commercial banana plantation where GCTCV218 was compared with Grand Naine grown in bare soil or with Arachis pintoi groundcover and with the application of a biocontrol product. Disease incidence, severity and plant growth parameters were determined at biweekly intervals in the greenhouse and monthly intervals in the field experiment. To understand changes in soil microbial activity, soil enzyme activity and Community Level Physiological Profiles (CLPP) were determined in both experiments. In the greenhouse experiment, there was increased FDA enzymatic activity with GCTCV218. Similarly, in the field experiment there was greater CLPP diversity and utilisation of the organic and amino acids under the cultivar GCTCV218. GCTCV218 significantly reduced disease incidence, 7.5% relative to Grand Naine 37.3 % after 12 months. The biocontrol and groundcovers had no significant effects on disease or soil microbial activity over the course of the two experiments. The resistance of GCTCV218 could be due to changes in the microbial profile relative to Grand Naine, but this requires further investigation. However, the results indicated that the cultivar GCTCV218 could be part of a solution for small holder banana growers affected by TR4 in the Philippines.